The attachment of stem cells to specialized functional niches instructs stem cell maintenance, with loss of adhesion associated with differentiation driven by cell-intrinsic programs. Id transcription factors are now shown to link cell-intrinsic maintenance programs and extrinsic cues by promoting adhesion of neural stem cells to the niche.
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Lathia, J., Rich, J. Holding on to stemness. Nat Cell Biol 14, 450–452 (2012). https://doi.org/10.1038/ncb2498
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DOI: https://doi.org/10.1038/ncb2498