Mitotic chromosome condensation has fascinated biologists since Flemming's early illustrations of mitosis in the late nineteenth century. Now — 130 years later — chromatid condensation is reconstituted in vitro with the minimum components. The results are remarkably and beautifully simple, requiring only core histones, three histone chaperones, topoisomerase II and condensin I.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hirano, T. & Mitchison, T. J. Cell 79, 449–458 (1994).
Saitoh, N. et al. J. Cell Biol. 127, 303–318 (1994).
Saka, Y. et al., EMBO J. 13, 4938–4952 (1994).
Strunnikov, A. V., Hogan, E. & Koshland, D. Genes Dev. 9, 587–599 (1995).
Hirano, T. & Mitchison, T. J. J. Cell Biol. 120, 601–612 (1993).
Hirano, T. Nat. Rev. Mol. Cell Biol. 7, 311–322 (2006).
MacCallum, D. E. et al. Mol. Biol. Cell 13, 25–39 (2002).
Wang, B. D. et al. Mol. Cell Biol. 25, 7216–7225 (2005).
Ono, T. et al. Mol. Biol. Cell 15, 3296–3308 (2004).
Hirano, T. Curr. Biol. 15, R265–R275 (2005).
Shintomi, K., Takahashi, T. S. & Hirano, T. Nat. Cell Biol. 17, 1014–1023 (2015).
Luger, K. et al. Nature 389, 251–260 (1997).
Philpott, A. & Leno, G. H. Cell 69, 759–67 (1992).
Akey, C. W. & Luger, K. Curr. Opin. Struct. Biol. 13, 6–14 (2003).
Kimura, K. et al. Science 282, 487–490 (1998).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Bell, J., Straight, A. Condensing chromosome condensation. Nat Cell Biol 17, 964–965 (2015). https://doi.org/10.1038/ncb3212
Published:
Issue Date:
DOI: https://doi.org/10.1038/ncb3212
This article is cited by
-
Roles of eukaryotic topoisomerases in transcription, replication and genomic stability
Nature Reviews Molecular Cell Biology (2016)