Two studies show that the E3 ubiquitin ligase RNF138 is recruited to DNA double-strand break sites, where it ubiquitylates key repair factors to promote DNA-end resection and homologous recombination. These findings add insights into the multilayered regulatory mechanisms underlying DNA double-strand break repair pathway choice in mammalian cells.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Chapman, J. R., Taylor, M. R. & Boulton, S. J. Mol. Cell 47, 497–510 (2012).
Bekker-Jensen, S. & Mailand, N. DNA Repair 9, 1219–1228 (2010).
Ismail, I. H. et al. Nat. Cell Biol. 17, 1446–1457 (2015).
Schmidt, C. K. et al. Nat. Cell Biol. 17, 1458–1470 (2015).
Lieber, M. R. Annu. Rev. Biochem. 79, 181–211 (2010).
Heyer, W. D., Ehmsen, K. T. & Liu, J. Annu. Rev. Genet. 44, 113–139 (2010).
Jackson, S. P. & Durocher, D. Mol. Cell 49, 795–807 (2013).
Murakawa, Y. et al. Cancer Res. 67, 8536–8543 (2007).
Feng, L. & Chen, J. Nat. Struct. Mol. Biol. 19, 201–206 (2012).
Postow, L. & Funabiki, H. Cell Cycle 12, 587–595 (2013).
Dantuma, N. P., Acs, K. & Luijsterburg, M. S. Exp. Cell Res. 329, 9–17 (2014).
Makharashvili, N. & Paull, T. T. DNA Repair 32, 75–81 (2015).
Povlsen, L. K. et al. Nat. Cell Biol. 14, 1089–1098 (2012).
Elia, A. E. et al. Mol. Cell 59, 867–881 (2015).
Nishi, R. et al. Nat. Cell Biol. 16, 1016–1026 (2014).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Bekker-Jensen, S., Mailand, N. RNF138 joins the HR team. Nat Cell Biol 17, 1375–1377 (2015). https://doi.org/10.1038/ncb3262
Published:
Issue Date:
DOI: https://doi.org/10.1038/ncb3262
This article is cited by
-
Multiple E3 ligases control tankyrase stability and function
Nature Communications (2023)
-
RING finger 138 deregulation distorts NF-кB signaling and facilities colitis switch to aggressive malignancy
Signal Transduction and Targeted Therapy (2022)
-
The deubiquitinase OTUD5 regulates Ku80 stability and non-homologous end joining
Cellular and Molecular Life Sciences (2019)