Several markers of gastric stem cells have been identified in recent years. Now a study demonstrates that Lgr5 marks a population of reserve stem cells located at the base of the corpus glands of the gastric epithelium, and that these cells can also act as a cell-of-origin for gastric tumorigenesis.
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Phesse, T., Sansom, O. Lgr5 joins the club of gastric stem cell markers in the corpus. Nat Cell Biol 19, 752–754 (2017). https://doi.org/10.1038/ncb3567
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DOI: https://doi.org/10.1038/ncb3567