Small RNAs generated at DNA break sites are implicated in mammalian DNA repair. Now, a study shows that following the formation of DNA double-strand breaks, bidirectional transcription events adjacent to the break generate small RNAs that trigger the DNA damage response by local RNA:RNA interactions.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
ATR-binding lncRNA ScaRNA2 promotes cancer resistance through facilitating efficient DNA end resection during homologous recombination repair
Journal of Experimental & Clinical Cancer Research Open Access 30 September 2023
-
Long non-coding RNA ANRIL promotes homologous recombination-mediated DNA repair by maintaining ATR protein stability to enhance cancer resistance
Molecular Cancer Open Access 05 July 2021
-
Specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions
Nature Communications Open Access 18 June 2020
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Khanna, K. K. & Jackson, S. P. Nat. Genet. 27, 247–254 (2001).
Michelini, F. et al. Nat. Cell Biol. 19, 1400–1411 (2017).
Penny, G. D., Kay, G. F., Sheardown, S. A., Rastan, S. & Brockdorff, N. Nature 379, 131–137 (1996).
Hacisuleyman, E. et al. Nat. Struct. Mol. Biol. 21, 198–206 (2014).
Lee, S. et al. Cell 164, 69–80 (2016).
Aymard, F. et al. Nat. Struct. Mol. Biol. 21, 366–374 (2014).
Wei, L. et al. Proc. Natl Acad. Sci. USA 112, E3495–E3504 (2015).
Chakraborty, A. et al. Nat. Commun. 7, 13049 (2016).
Keskin, H. et al. Nature 515, 436–439 (2014).
Francia, S. et al. Nature 488, 231–235 (2012).
Wei, W. et al. Cell 149, 101–112 (2012).
Michalik, K. M., Bottcher, R. & Forstemann, K. Nucleic Acids Res. 40, 9596–9603 (2012).
Burger, K. et al. J. Cell Biol. 216, 2373–2389 (2017).
Ohle, C. et al. Cell 167, 1001–1013 (2016).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Storici, F., Tichon, A. RNA takes over control of DNA break repair. Nat Cell Biol 19, 1382–1384 (2017). https://doi.org/10.1038/ncb3645
Published:
Issue Date:
DOI: https://doi.org/10.1038/ncb3645
This article is cited by
-
ATR-binding lncRNA ScaRNA2 promotes cancer resistance through facilitating efficient DNA end resection during homologous recombination repair
Journal of Experimental & Clinical Cancer Research (2023)
-
Long non-coding RNA ANRIL promotes homologous recombination-mediated DNA repair by maintaining ATR protein stability to enhance cancer resistance
Molecular Cancer (2021)
-
Specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions
Nature Communications (2020)