Natural products contain a range of chemical structures optimized for biological interactions. Fragmenting these compounds could help to combine this diversity with the broad coverage of chemical space offered by fragment-based drug discovery, and help to improve the efficiency with which screening hits can become successful drugs.
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Shoichet, B. Nature's pieces. Nature Chem 5, 9–10 (2013). https://doi.org/10.1038/nchem.1537
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DOI: https://doi.org/10.1038/nchem.1537
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