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C–H activation

Following directions

Nature Chemistry volume 7, pages 686–687 (2015)Cite this article

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Controlling the site-selectivity of C–H activation reactions is a major obstacle for the development of synthetically useful methodology. Now, meta-C–H functionalizations of arenes have been achieved by exploiting weak secondary interactions of a metal-coordinating ligand with the substrate.

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Figure 1: Strategies for meta-selective C–H functionalization.

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Authors and Affiliations

  1. Lutz Ackermann and Jie Li are at the Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstr. 2, 37077 Göttingen, Germany,

    Lutz Ackermann & Jie Li

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  1. Lutz Ackermann
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  2. Jie Li
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Correspondence to Lutz Ackermann.

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Ackermann, L., Li, J. Following directions. Nature Chem 7, 686–687 (2015). https://doi.org/10.1038/nchem.2334

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