Understanding the mechanisms that determine cell fate under endoplasmic reticulum (ER) stress had been hampered by the lack of models to study unfolded protein response (UPR) adaptive phases. The development of an engineered protein to conditionally induce its misfolding allowed the establishment of a resolvable ER stress condition.
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Medinas, D., Hetz, C. Modeling UPR adaptive responses. Nat Chem Biol 10, 879–880 (2014). https://doi.org/10.1038/nchembio.1653
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DOI: https://doi.org/10.1038/nchembio.1653