By converting prolyl to 4-hydroxyprolyl residues, prolyl hydroxylases induce a conformational bias into proteins. This conformational preference is a result of a stereoelectronic gauche effect and is crucial for protein-protein recognition in oxygen sensing.
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Fujimori, D. Hypoxia sensing goes gauche. Nat Chem Biol 5, 202–203 (2009). https://doi.org/10.1038/nchembio0409-202
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DOI: https://doi.org/10.1038/nchembio0409-202
