Abstract
Serious paravalvular leakage occurs in 1–5% of patients who have undergone surgical cardiac valve replacement procedures. Clinical manifestations include hemolysis, heart failure and arrhythmias. Presently, the gold standard treatment for severe paravalvular leakage is surgery; however, the outcomes remain far from optimum. In this Review we discuss the problem of paravalvular leak and focus on the role of percutaneous repair as a treatment option.
Key Points
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Serious paravalvular leak following valve replacement occurs in 1–5% of patients
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Severe paravalvular leaks can clinically manifest as heart failure, hemolysis and arrhythmias
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Repeat surgery is associated with considerable morbidity in some patients; percutaneous treatment should be considered in these patients on an individual basis, taking into consideration patient preference and operator and center experience
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Percutaneous repair of paravalvular leaks can be safely and effectively achieved using modification of currently available equipment and devices
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Bhindi, R., Bull, S., Schrale, R. et al. Surgery Insight: percutaneous treatment of prosthetic paravalvular leaks. Nat Rev Cardiol 5, 140–147 (2008). https://doi.org/10.1038/ncpcardio1112
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DOI: https://doi.org/10.1038/ncpcardio1112