Abstract
The randomized, placebo-controlled trial reported by Montorsi and colleagues attempted to determine if nightly vardenafil was more effective than on-demand drug in restoring erectile function after radical prostatectomy. No significant difference in outcomes was found between the study groups at 11 or 13 months after surgery. The study, however, had enough methodological flaws to prevent any definitive conclusions from being drawn. The authors' conclusion that the data support a shift towards on-demand phosphodiesterase 5 inhibitor use after radical prostatectomy is not supported by the data.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Montorsi F et al. (1997) Recovery of spontaneous erectile function after nerve-sparing radical retropubic prostatectomy with and without early intracavernous injections of alprostadil: results of a prospective, randomized trial. J Urol 158: 1408–1410
Padma-Nathan H et al. (2008) Randomized, double-blind, placebo-controlled study of postoperative nightly sildenafil citrate for the prevention of erectile dysfunction after bilateral nerve-sparing radical prostatectomy. Int J Impot Res 20: 479–486
Mulhall J et al. (2005) The use of an erectogenic pharmacotherapy regimen following radical prostatectomy improves recovery of spontaneous erectile function. J Sex Med 2: 532–540
Bannowsky A et al. (2008) Recovery of erectile function after nerve-sparing radical prostatectomy: improvement with nightly low dose sildenafil. BJU Int 101: 1279–1283
Montorsi F et al. (2008) Effect of nightly versus on-demand vardenafil on recovery of erectile function in men following bilateral nerve-sparing radical prostatectomy. Eur Urol 54: 924–931
Teloken P et al. (2007) The correlation between erectile function and patient satisfaction. J Sex Med 4: 472–476
Ghofrani HA et al. (2004) Differences in hemodynamic and oxygenation responses to three different phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension: a randomized prospective study. J Am Coll Cardiol 44: 1488–1496
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Mulhall, J. Does on-demand vardenafil improve erectile function recovery after radical prostatectomy?. Nat Rev Urol 6, 14–15 (2009). https://doi.org/10.1038/ncpuro1271
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/ncpuro1271
This article is cited by
-
The role and structure of a postradical prostatectomy penile rehabilitation program
Current Prostate Reports (2009)
-
The role and structure of a postradical prostatectomy penile rehabilitation program
Current Urology Reports (2009)