Abstract
RAT embryo cells infected with either CF-1 or Rauscher C-type RNA murine leukaemia virus, when treated with diethylnitrosamine (DENA), undergo morphological transformation and become aneuploid1. Untreated cells and cells treated with either virus or chemical alone do not transform. We describe here a similar effect of 3-methylcholanthrene (3 MC) on rat cells infected with Rauscher leukaemia virus.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
We are sorry, but there is no personal subscription option available for your country.
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Freeman, A. E., Price, P. J., Igel, H. I., Young, J. C., Maryak, J. M., and Huebner, R. J., J. Nat. Cancer Inst., 44, 65 (1970).
Moorhead, P. S., Nowell, P. C., Mellman, W. J., Battips, D. M., and Hungerford, D. A., Exp. Cell Res., 20, 613 (1960).
Hartley, J. W., Rowe, W. P., Capps, W. I., and Huebner, R. J., J. Virol., 3, 126 (1969).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
PRICE, P., FREEMAN, A., LANE, W. et al. Morphological Transformation of Rat Embryo Cells by the Combined Action of 3-Methylcholanthrene and Rauscher Leukaemia Virus. Nature New Biology 230, 144–146 (1971). https://doi.org/10.1038/newbio230144a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/newbio230144a0