Abstract
SEVERAL endocrine cell lines established in recent years show a functional response to hormones in vitro1 but, except for one mammary cell line2, none of them exhibits the normal hormone requirement for growth in vivo. We have now isolated a rat ovarian cell line whose growth in vitro is markedly stimulated by bovine luteinizing hormone (LH-NIH-B7), a pituitary gonadotrophin, and by dexamethasone, a synthetic glucocorticoid. This cell line provides the first permanent in vitro system for studying the growth stimulation of gonadal cells by hormones.
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CLARK, J., JONES, K., GOSPODAROWICZ, D. et al. Growth Response to Hormones by a New Rat Ovary Cell Line. Nature New Biology 236, 180–181 (1972). https://doi.org/10.1038/newbio236180a0
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DOI: https://doi.org/10.1038/newbio236180a0
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