Abstract
HUMAN foetal haemoglobin (Hb-F) of the newborn is a heterogeneous protein, with two types of γ chains differing minimally in position 136 which is occupied either by a glycyl residue or by an alanyl residue1. The phenomenon is worldwide and is not limited to specific races or geographic areas2. This and other evidence points to the two types of γ chains, termed the Gγ and Aγ chains, being the products of non-allelic structural genes1.
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References
Schroeder, W. A., Huisman, T. H. J., Shelton, J. R., Shelton, J. B., Kleihauer, E. F., Dozy, A. M., and Robberson, B., Proc. US Nat. Acad. Sci., 61, 930 (1968).
Schroeder, W. A., Shelton, J. R., Shelton, J. B., Apell, G., Huisman, T. H. J., and Bouver, N. G., Nature New Biology, 240, 273 (1972).
Schroeder, W. A., Huisman, T. H. J., Brown, A. K., Uy, R., Bouver, N. G., Lerch, P. O., Shelton, J. R., Shelton, J. B., and Apell, G., Pediat. Res., 5, 493 (1971).
Huisman, T. H. J., and Schroeder, W. A., CRC. Crit. Rev. Clin. Lab. Sci., 1, 471 (1970).
Huisman, T. H. J., and Schroeder, W. A., in Synthese, Structur und Function des Hämoglobins (edit. by Martin and Nowicki) (Lehmanns Verlag, München, 1972).
Huisman, T. H. J., Schroeder, W. A., Bannister, W. H., and Grech, J. L., Biochem. Genetics, 7, 131 (1972).
Huisman, T. H. J., Clin. Chim. Acta, 40, 159 (1972).
Schroeder, W. A., Huisman, T. H. J., Shelton, J. R., and Wilson, J. B., Anal. Biochem., 35, 234 (1970).
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SCHROEDER, W., BANNISTER, W., GRECH, J. et al. Non-synchronized Suppression of Postnatal Activity in Non-allelic Genes which Synthesize the Gγ Chain in Human Foetal Haemoglobin. Nature New Biology 244, 89–90 (1973). https://doi.org/10.1038/newbio244089a0
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DOI: https://doi.org/10.1038/newbio244089a0
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