Researchers have found that carriers of the Huntington's disease gene develop subtle, but distinctive deficiencies in their arm movements up to seven years before they show symptoms of the disease.
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References
Smith,M. A., Brandt J. & Shadmehr, R. Motor disorder in Huntington's disease begins as a dysfunction in error feedback control. Nature 403, 544 2000.
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Abdulla, S. Huntington's hunt homes in. Nature (2000). https://doi.org/10.1038/news000203-9
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DOI: https://doi.org/10.1038/news000203-9