To understand transcriptional regulation, it is necessary to understand the factors that determine where a particular transcription factor binds in the genome. A new study demonstrates that a single protein, FoxA1, can dictate the global DNA binding profile and the transcriptional function of estrogen receptor a in breast cancer cells and in other cell types.
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References
Carroll, J.S. et al. Nat. Genet. 38, 1289–1297 (2006).
Lin, C.Y. et al. PLoS Genet. 3, e87 (2007).
Fullwood, M.J. et al. Nature 462, 58–64 (2009).
Lupien, M. et al. Cell 132, 958–970 (2008).
Carroll, J.S. et al. Cell 122, 27–33 (2005).
Hurtado, A. et al. Nat. Genet. 43, 27–33 (2011).
Green, K.A. & Carroll, J.S. Nat. Rev. Cancer 7, 713–722 (2007).
Cirillo, L.A. et al. EMBO J. 17, 244–254 (1998).
Cirillo, L.A. et al. Mol. Cell 9, 279–289 (2002).
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Cheung, E., Ruan, Y. Determination of transcription factor binding. Nat Genet 43, 11–12 (2011). https://doi.org/10.1038/ng0111-11
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DOI: https://doi.org/10.1038/ng0111-11