A microarray-based study of the nematode Caenorhabditis elegans offers a first glimpse of the effect of mutation accumulation on transcriptional variation. One major conclusion is that stabilizing selection must constrain the divergence of gene expression profiles in natural populations.
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Gibson, G. Mutation accumulation of the transcriptome. Nat Genet 37, 458–460 (2005). https://doi.org/10.1038/ng0505-458
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DOI: https://doi.org/10.1038/ng0505-458