Identical mutations of the same genes can lead either to congenital malformations or to cancer, depending on their cellular and temporal context. The demonstration of activated RAS-ERK signaling in a mouse model of Apert syndrome suggests that drugs designed to inhibit this pathway in cancer may also delay the progression of several serious pediatric syndromes.
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Wilkie, A. Cancer drugs to treat birth defects. Nat Genet 39, 1057–1059 (2007). https://doi.org/10.1038/ng0907-1057
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DOI: https://doi.org/10.1038/ng0907-1057
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