The Oct4 transcription factor has a critical role in the maintenance of pluripotent stem cells in an undifferentiated state and in the formation of mammalian germ cells. Recent work demonstrates that a specific nuclear receptor is involved in regulating the expression of Oct4 itself. This finding has important implications for understanding pluripotent stem-cell biology and nuclear reprogramming.
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References
Pesce, M., Gross, M. K. & Schöler, H. R. Bioessays 20, 722–732 (1998).
Fuhrmann, G. et al. Dev. Cell 1, 377–387 (2001).
Nichols, J. et al. Cell 95, 379–391 (1998).
Niwa, H., Miyazaki, J. & Smith, A.G. Nature Genet. 24, 372–376 (2000).
Pikarsky, E., Sharir, H., Ben-Shushan, E. & Bergman, Y. Mol. Cell. Biol. 14, 1026–1038 (1994).
Schoorlemmer, J. et al. Mol. Cell. Biol. 14, 1122–1136 (1994).
Sylvester, I. & Schöler, H. R. Nucleic Acids Res. 22, 901–911 (1994).
Ben-Shushan, E., Sharir, H., Pikarsky, E. & Bergman, Y. Mol. Cell. Biol. 15, 1034–1048 (1995).
Fuhrmann, G., Sylvester, I. & Schöler, H. R. Cell. Mol. Biol. (Noisy-le-grand) 45, 717–724. (1999).
Chen, F., Cooney, A. J., Wang, Y., Law, S. W. & O'Malley, B. W. Mol. Endocrinol. 8, 1434–1444 (1994).
Ben-Shushan, E., Pikarsky, E., Klar, A. & Bergman, Y. Mol. Cell. Biol. 13, 891–901 (1993).
El-Osta, A. & Wolffe, A.P. Gene Exp. 9, 63–75 (2000).
Nagy, L. et al. Cell 89, 373–380 (1997).
Alland, L. et al. Nature 387, 49–55 (1997).
Heinzel, T. et al. Nature 387, 43–48 (1997).
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Donovan, P. High Oct-ane fuel powers the stem cell. Nat Genet 29, 246–247 (2001). https://doi.org/10.1038/ng1101-246
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DOI: https://doi.org/10.1038/ng1101-246
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