Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Transcription in the loop

Nature Genetics volume 38, pages 1229–1230 (2006)Cite this article

A new study shows that during transcription, the TH2 interleukin gene cluster is organized into several small chromatin loops connected at their base by the protein SATB1. This first detailed glimpse of chromatin folding provides a new perspective on the coordination of cell type–specific gene expression.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Chromatin loops and coordination of gene transcription.

Kim Caesar

References

  1. Wilson, C.B. & Merkenschlager, M. Curr. Opin. Immunol. 18, 143–151 (2006).

    Article  CAS  Google Scholar 

  2. Lee, G.R., Kim, S.T., Spilianakis, C.G., Fields, P.E. & Flavell, R.A. Immunity 24, 369–379 (2006).

    Article  CAS  Google Scholar 

  3. Spilianakis, C., Lalioti, M., Town, T., Lee, G. & Flavell, R.A. Nature 435, 637–645 (2005).

    Article  CAS  Google Scholar 

  4. Cai, S., Lee, C.C. & Kohwi-Shigematsu, T. Nat. Genet. 38, 1278–1288 (2006).

    Article  CAS  Google Scholar 

  5. Dickinson, L.A., Joh, T., Kohwi, Y. & Kohwi-Shigematsu, T. Cell 70, 631–645 (1992).

    Article  CAS  Google Scholar 

  6. Alvarez, J.D. et al. Genes Dev. 14, 521–535 (2000).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Cai, S., Han, H.J. & Kohwi-Shigematsu, T. Nat. Genet. 34, 42–51 (2003).

    Article  CAS  Google Scholar 

  8. Dekker, J. Nat. Methods 3, 17–21 (2006).

    Article  CAS  Google Scholar 

  9. Horike, S., Cai, S., Miyano, M., Cheng, J.F. & Kohwi-Shigematsu, T. Nat. Genet. 37, 31–40 (2005).

    Article  CAS  Google Scholar 

  10. Gasser, S.M. Science 296, 1412–1416 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Development and Genetics, Evolution Biology Centre, Norbyvägan 18A, Uppsala University, Uppsala, SE-752 36, Sweden

    Anita Göndör & Rolf Ohlsson

Authors
  1. Anita Göndör
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rolf Ohlsson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Göndör, A., Ohlsson, R. Transcription in the loop. Nat Genet 38, 1229–1230 (2006). https://doi.org/10.1038/ng1106-1229

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng1106-1229

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing