Fat accumulation in the liver is a common trait that may progress to severe liver disease. A new study identifies common and rare nonsynonymous variants in PNPLA3 that are associated with hepatic triglyceride content and that may explain some of the population differences in prevalence.
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Mohlke, K. Nonsynonymous variants and fatty liver disease. Nat Genet 40, 1394–1395 (2008). https://doi.org/10.1038/ng1208-1394
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DOI: https://doi.org/10.1038/ng1208-1394