Abstract
We examined the coding sequence of 518 protein kinases, ∼1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Manning, G., Whyte, D.B., Martinez, R., Hunter, T. & Sudarsanam, S. Science 298, 1912–1934 (2002).
Huang, M.E., Rio, A.G., Nicolas, A. & Kolodner, R.D. Proc. Natl. Acad. Sci. USA. 100, 11529–11534 (2003).
Xiao, W., Fontanie, T., Bawa, S. & Kohalmi, L. Mutat. Res. 431, 155–165 (1999).
Wagner, E. & Lykke-Andersen, J. J. Cell Sci. 115, 3033–3038 (2002).
Persons, D.L., Borelli, K.A. & Hsu, P.H. Mod. Pathol. 10, 720–727 (1997).
Wang, T.L. et al. Proc. Natl. Acad. Sci. USA 99, 3076–3080 (2002).
Olivier, M. et al. Hum. Mutat. 19, 607–614 (2002).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Supplementary information
Supplementary Table 1
Mutation data for the primary and secondary screen (PDF 47 kb)
Supplementary Table 2
Genes analysed in the primary and secondary screens (XLS 66 kb)
Supplementary Table 3
Samples. (PDF 40 kb)
Supplementary Table 4
Coding strand. (PDF 52 kb)
Supplementary Table 5
Pyrimidine strand. (PDF 51 kb)
Rights and permissions
About this article
Cite this article
Stephens, P., Edkins, S., Davies, H. et al. A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer. Nat Genet 37, 590–592 (2005). https://doi.org/10.1038/ng1571
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/ng1571
This article is cited by
-
Mechanisms of APOBEC3 mutagenesis in human cancer cells
Nature (2022)
-
Multi-layered proteomic analyses decode compositional and functional effects of cancer mutations on kinase complexes
Nature Communications (2020)
-
Somatic mutations in the DNA repairome in prostate cancers in African Americans and Caucasians
Oncogene (2020)
-
Next-Generation Sequencing Identifies Novel RTK VUSs in Breast Cancer with an Emphasis on ROS1, ERBB4, ALK and NTRK3
Pathology & Oncology Research (2020)
-
Germline APOBEC3B deletion influences clinicopathological parameters in luminal-A breast cancer: evidences from a southern Brazilian cohort
Journal of Cancer Research and Clinical Oncology (2020)