The unfolded protein response produces modified endogenous RNA substrates for host cytosolic sensors of RNA, which may lead to production of the interferons IFN-α and IFN-β. The accrual of modified RNA is prevented by an RNA nuclease.
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Wang, Y., Colonna, M. RNA exosomes keep endogenous RNA under the radar. Nat Immunol 15, 830–831 (2014). https://doi.org/10.1038/ni.2966
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DOI: https://doi.org/10.1038/ni.2966