Dendritic cells can internalize and degrade invading pathogens in phagosomes, yet some HIV-1 particles can evade this degradation process and productively infect dendritic cells. New data show that HIV-1 replication is triggered by signal-transduction events through Toll-like receptor 8 and DC-SIGN.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Gringhuis, S.I. et al. Nat. Immunol. 11, 419–426 (2010).
Banchereau, J. & Steinman, R.M. Nature 392, 245–252 (1998).
McDonald, D. et al. Science 300, 1295–1297 (2003).
Geijtenbeek, T.B. et al. Cell 100, 587–597 (2000).
Smed-Sorensen, A. et al. J. Virol. 79, 8861–8869 (2005).
McIlroy, D. et al. J. Virol. 69, 4737–4745 (1995).
Wu, L. & KewalRamani, V.N. Nat. Rev. Immunol. 6, 859–868 (2006).
Piguet, V. & Steinman, R.M. Trends Immunol. 28, 503–510 (2007).
Cavrois, M., Neidleman, J., Kreisberg, J.F. & Greene, W.C. PLoS Pathog. 3, e4 (2007).
Wu, L., Martin, T.D., Vazeux, R., Unutmaz, D. & KewalRamani, V.N. J. Virol. 76, 5905–5914 (2002).
Gummuluru, S., Rogel, M., Stamatatos, L. & Emerman, M. J. Virol. 77, 12865–12874 (2003).
Baribaud, F., Pöhlmann, S., Leslie, G., Mortari, F. & Doms, R.W. J. Virol. 76, 9135–9142 (2002).
Lambert, A.A., Gilbert, C., Richard, M., Beaulieu, A.D. & Tremblay, M.J. Blood 112, 1299–1307 (2008).
Martinson, J.A. et al. Cell. Immunol. 250, 75–84 (2007).
de Witte, L. et al. Nat. Med. 13, 367–371 (2007).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Tremblay, M. HIV-1 and pattern-recognition receptors: a marriage of convenience. Nat Immunol 11, 363–365 (2010). https://doi.org/10.1038/ni0510-363
Issue Date:
DOI: https://doi.org/10.1038/ni0510-363