Regulatory T cells have the remarkable ability to suppress immune responses driven by different types of effector T cells. Two recent studies, documenting important functions for T-bet and IRF4 in regulatory T cells, demonstrate that this ability requires the expression of transcription factors typically associated with effector T cell function.
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Barnes, M., Powrie, F. Hybrid Treg cells: steel frames and plastic exteriors. Nat Immunol 10, 563–564 (2009). https://doi.org/10.1038/ni0609-563
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DOI: https://doi.org/10.1038/ni0609-563
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