The receptor for the lipid mediator sphingosine 1-phosphate is critical for T cell trafficking. New data show that signaling mediated by this receptor critically controls the development, maintenance and suppressive activity of natural regulatory T cells that express the transcription factor Foxp3.
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Ohkura, N., Sakaguchi, S. A novel modifier of regulatory T cells. Nat Immunol 10, 685–686 (2009). https://doi.org/10.1038/ni0709-685
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DOI: https://doi.org/10.1038/ni0709-685
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