Autoimmune diseases are more prevalent in women than men. A new interest in understanding the biology of this difference as well as funding opportunities have focused attention on research priorities in sex differences.
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References
Beeson, P. B. Am. J. Med. 96, 457–462 (1994).
Fishman, J. R., Wick, J. G. & Koenig, B. A. Agenda for Research on Women's Health for the 21st Century: NIH Publication 99-4385. Vol.2, 15–19 (NIH, Bethesda, MD, 1999).
Jawaheer, D. et al. Am. J. Hum. Genet. 68, 927–936 (2001).
Collier, E., Diamond, B., Weinblatt, A. C., Whitacre, C. & Mitchell, K. C. Agenda for Research on Women's Health for the 21st Century: NIH Publication 99-4386. Vol. 2, 93–100. (NIH, Bethesda, MD,1999).
Whitacre, C. C. et al. Sex Differences in Autoimmune Disease: Focus on Multiple Sclerosis. Science (1999). http://www.sciencemag.org/feature/data/983519.shl.
Whitacre, C. C., Reingold, S. C. & O'Looney, P. A. & Task Force on Gender, Multiple Sclerosis and Autoimmunity Science 283, 1277–1278 (1999).
National Institutes of Health Report of the Autoimmune Diseases Coordinating Committee. (2000) http://www.niaid.nih.gov/publications/autoimmune.htm.
Wizemann, T. M. & and Pardue, M.-L. Exploring the Biological Contributions to Human Health: Does sex matter? (Board on Health Sciences Policy, Institute of Medicine, 2001).
Eidinger, D. & Garrett, T. J. Exp. Med. 136, 1098–1116 (1972).
Weinstein, Y., Ran, S. & Segal, S. J. Immunol. 132, 656–661 (1984).
Michaels, R. & Rogers, K. Pediatrics 47, 120–123 (1971).
Vranckx, R., Muylle, L., Cole, J., Moldenhaser, R. & Peetermans, M. Vox Sang. 50, 220–222 (1986).
Amadori, A. et al. Nature Med. 1, 1279–1283 (1995).
Huygen, K. & Palfliet, K. Cell. Immunol. 85, 75–81 (1984).
Wynn, D., Rodriguez, M., O'Fallon, W. M. & Kurland, L. T. Neurology 40, 780–786 (1990).
Gilmore, W., Weiner, L. & Correale, J. J. Immunol. 158, 446–451 (1997).
Araneo, B., Dowell, T., Diegel, M. & Daynes, R. Blood 78, 688–699 (1991).
Nelson, J. & Ostensen, M. Rheum. Dis. Clin. N. Am. 23, 195–212 (1997).
Confavreux, C., Hutchinson, M., Hours, M. M., Cortinovis-Tourniaire, P. & Moreau T. N. Engl. J. Med. 339, 285–291 (1998).
Silver, R. & Branch, D. Clin. Obstet. Gynaecol. 6, 565–600 (1992).
Lockshin, M. Arthritis Rheum. 32, 665–670 (1989).
Petri, M. Rheum. Dis. Clin. N. Am. 20, 87–118 (1994).
Spector, T. D. et al. Clin Rheumatol. 8, 37–41 (1989).
Nelson, J. L. Lupus 8, 370–374 (1999).
Nelson, J. L. et al. N. Engl. J. Med. 329, 466–471 (1993).
Jansson, L. & Holmdahl, R. Inflamm. Res. 47, 290–301 (1998).
Kim, S, Liva, S. M., Dalal, M. A., Verity, M. A. & Voskuhl, R.R. Neurology 52, 1230–1238 (1999).
Dalal, M., Kim, S. & Voskuhl, R. R. J. Immunol. 159, 3–6 (1997).
Wilder, R. Annu. Rev. Immunol. 13, 307–338 (1995).
Griffin, A. C. & Whitacre, C. C. J. Neuroimmunol. 35, 53–64 (1991).
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Whitacre, C. Sex differences in autoimmune disease. Nat Immunol 2, 777–780 (2001). https://doi.org/10.1038/ni0901-777
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DOI: https://doi.org/10.1038/ni0901-777
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