Entry of leukocytes into tissues is a key feature of inflammation. New data suggest the polysaccharide heparan sulfate is required for several stages of this entry process.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Overexpression of heparanase enhances T lymphocyte activities and intensifies the inflammatory response in a model of murine rheumatoid arthritis
Scientific Reports Open Access 12 April 2017
-
Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-β in murine brain
Acta Neuropathologica Open Access 13 June 2012
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Turnbull, J., Powell, A. & Guimond, S. Trends Cell Biol. 11, 75–82 (2001).
Esko, J.D. & Selleck, S.B. Annu. Rev. Biochem. 71, 435–471 (2002).
Gotte, M. FASEB J. 17, 575–591 (2003).
Middleton, J. et al. Cell 91, 385–395 (1997).
Wang, L., Fuster, M., Sriramarao, P. & Esko, J.D. Nat. Immunol. 6, 902–910 (2005).
Lowe, J.B. Immunol. Rev. 186, 19–36 (2002).
Kannagi, R. Curr. Opin. Struct. Biol. 12, 599–608 (2002).
Ley, K. Microcirculation 10, 289–295 (2003).
Rosen, S.D. Annu. Rev. Immunol. 22, 129–156 (2004).
Nelson, R.M. et al. Blood 82, 3253–3258 (1993).
Wang, L., Brown, J.R., Varki, A. & Esko, J.D. J. Clin. Invest. 110, 127–136 (2002).
Freeman, C. et al. J. Biol. Chem. 280, 8842–8849 (2005).
Acknowledgements
The author thanks the National Health and Medical Research Council of Australia for support.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Parish, C. Heparan sulfate and inflammation. Nat Immunol 6, 861–862 (2005). https://doi.org/10.1038/ni0905-861
Issue Date:
DOI: https://doi.org/10.1038/ni0905-861
This article is cited by
-
The Influence of Heparan Sulfate on Breast Amyloidosis and the Toxicity of the Pre-fibrils Formed by β-casein
The Protein Journal (2022)
-
Overexpression of heparanase enhances T lymphocyte activities and intensifies the inflammatory response in a model of murine rheumatoid arthritis
Scientific Reports (2017)
-
Modulation of heparan sulfate in the glomerular endothelial glycocalyx decreases leukocyte influx during experimental glomerulonephritis
Kidney International (2014)
-
Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-β in murine brain
Acta Neuropathologica (2012)
-
Release of atrial natriuretic peptide precedes shedding of the endothelial glycocalyx equally in patients undergoing on- and off-pump coronary artery bypass surgery
Basic Research in Cardiology (2011)