Some individuals with colorectal cancer benefit from therapies targeting the epidermal growth factor receptor (EGFR). However, resistance to EGFR blockade inevitably occurs. The characterization of a new mechanism of resistance to the EGFR-specific antibody cetuximab provides clues into how therapeutic strategies might be designed to overcome this specific resistance mechanism (pages 221–223).
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References
Montagut, C. et al. Nat. Med. 18, 221–223 (2012).
Jonker, D.J. et al. N. Engl. J. Med. 357, 2040–2048 (2007).
Vermorken, J.B. et al. N. Engl. J. Med. 359, 1116–1127 (2008).
Karapetis, C.S. et al. N. Engl. J. Med. 359, 1757–1765 (2008).
De Roock, W. et al. Lancet Oncol. 11, 753–762 (2010).
Amado, R.G. et al. J. Clin. Oncol. 26, 1626–1634 (2008).
Bardelli, A. & Siena, S. J. Clin. Oncol. 28, 1254–1261 (2010).
Wadlow, R.C. et al. Oncologist published online, 10.1634/theoncologist.2011-0452 (30 December 2011).
Jänne, P.A., Gray, N. & Settleman, J. Nat. Rev. Drug Discov. 8, 709–723 (2009).
Yonesaka, K. et al. Sci. Transl. Med. 3, 99ra86 (2011).
Bertotti, A. et al. Cancer Discov. 1, 509–523 (2011).
Benavente, S. et al. Clin. Cancer Res. 15, 1585–1592 (2009).
Li, C., Iida, M., Dunn, E.F., Ghia, A.J. & Wheeler, D.L. Oncogene 28, 3801–3813 (2009).
Lu, Y. et al. Cancer Res. 67, 8240–8247 (2007).
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Bardelli, A., Jänne, P. The road to resistance: EGFR mutation and cetuximab. Nat Med 18, 199–200 (2012). https://doi.org/10.1038/nm.2646
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DOI: https://doi.org/10.1038/nm.2646
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