Anemia is a debilitating condition that can be complicated by ineffective erythropoiesis. Two new studies identify GDF11 as a regulator of erythropoiesis and show that its inhibition in mouse models of anemia with ineffective erythropoiesis restores normal erythropoietic differentiation and alleviates anemia (pages 398–407 and 408–414).
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Paulson, R. Targeting a new regulator of erythropoiesis to alleviate anemia. Nat Med 20, 334–335 (2014). https://doi.org/10.1038/nm.3524
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DOI: https://doi.org/10.1038/nm.3524
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