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Acknowledgements
We thank L. Toll, G.R. Pattison R. King, L. Xu, M. McConnell, C. Payne, D. Robertson, G. Botzet, K. Ambati and A. Uittenbogaard for technical assistance. J.A. was supported by National Eye Institute/US National Institutes of Health (NIH) grants DP1GM114862, R01EY018350, R01EY018836, R01EY020672 and R01EY022238, the Doris Duke Distinguished Clinical Scientist Award, the Burroughs Wellcome Fund Clinical Scientist Award in Translational Research, the Ellison Medical Foundation Senior Scholar in Aging Award, the Dr. E. Vernon Smith and Eloise C. Smith Macular Degeneration Endowed Chair, a Foundation Fighting Blindness Individual Investigator Research Award, the Carl Reeves Foundation, a Harrington Discovery Institute Scholar-Innovator Award and a Research to Prevent Blindness departmental unrestricted grant. Y.H. was supported by an Alcon Japan Research award. T.Y. was supported by a Fight for Sight postdoctoral award. B.J.F. was supported by NIH T32HL091812 and UL1RR033173. A.B.-C. was supported by the Programme for Advanced Medical Education (sponsored by Fundação Calouste Gulbenkian, Fundação Champalimaud, Ministério da Saúde and Fundação para a Ciência e Tecnologia, Portugal) and a Bayer Global Ophthalmology Research Award. N.K. was supported by NIH K99EY024336 and the Beckman Initiative for Macular Research. B.D.G. was supported by the American Heart Association and the International Retinal Research Foundation. B.K.A. was supported by NIH R01EY017182 and R01EY017950, a Veterans Affairs Merit Award and the Department of Defense. G.N. was supported by NIH R01AI063331 and R01AR052756. D.R.H. was supported by NIH P30EY003040 and R01EY001545 and the Arnold and Mabel Beckman Foundation. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
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Y.H., T.Y., T.M., V.T., R.Y., Y.K., A.B.-C., N.K., B.D.G., S.B., S.H., X.Z., M.N., R.I. and H.K. performed experiments. G.N., I.H. and H.N. provided animals and reagents. J.A. and B.J.F. wrote the paper with assistance from A.B.-C. The project was jointly directed by J.A., D.R.H., B.K.A., M.N., H.K., Y.O. and H.T. All authors had the opportunity to discuss the results and comment on the manuscript.
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J.A. is named as an inventor on US and PCT patent applications filed by his employer, The University of Kentucky, pertaining to inflammasome-modulating strategies for AMD described in this manuscript. iVeena, Inc., co-founded by B.K.A. and J.A., has licensed technologies related to AMD from The University of Kentucky.
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Hirano, Y., Yasuma, T., Mizutani, T. et al. IL-18 is not therapeutic for neovascular age-related macular degeneration. Nat Med 20, 1372–1375 (2014). https://doi.org/10.1038/nm.3671
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DOI: https://doi.org/10.1038/nm.3671
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