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CD47 blockade as another immune checkpoint therapy for cancer

Nature Medicine volume 21, pages 1122–1123 (2015)Cite this article

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The role of CD47—often expressed on tumor cells—as a 'don't eat me' signal that inhibits macrophage phagocytosis is well established. But new work reveals a major role for other immune cell types—T cells and dendritic cells—in the anti-tumor effects of therapeutic CD47 blockade.

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Figure 1: The CD47 immune checkpoint.

References

  1. Grimsley, C. & Ravichandran, K.S. Trends Cell Biol. 13, 648–656 (2003).

    Article  CAS  Google Scholar 

  2. McCracken, M.N., Cha, A.C. & Weissman, I.L. Clin. Cancer Res. 21, 3597–3601 (2015).

    Article  CAS  Google Scholar 

  3. Willingham, S.B. et al. Proc. Natl. Acad. Sci. USA 109, 6662–6667 (2012).

    Article  CAS  Google Scholar 

  4. Beatty, G.L. et al. Science 331, 1612–1616 (2011).

    Article  CAS  Google Scholar 

  5. Ruffell, B. & Coussens, L.M. Cancer Cell 27, 462–472 (2015).

    Article  CAS  Google Scholar 

  6. Liu, X. et al. Nat. Med. 21, 1209–1215 (2015).

    Article  CAS  Google Scholar 

  7. Sharma, P. & Allison, J.P. Cell 161, 205–214 (2015).

    Article  CAS  Google Scholar 

  8. Barrett, D.M., Singh, N., Porter, D.L., Grupp, S.A. & June, C.H. Annu. Rev. Med. 65, 333–347 (2014).

    Article  CAS  Google Scholar 

  9. Tseng, D. et al. Proc. Natl. Acad. Sci. USA 110, 11103–11108 (2013).

    Article  CAS  Google Scholar 

  10. Soto-Pantoja, D.R. et al. Cancer Res. 74, 6771–6783 (2014).

    Article  CAS  Google Scholar 

  11. Vonderheide, R.H. & Glennie, M.J. Clin. Cancer Res. 19, 1035–1043 (2013).

    Article  CAS  Google Scholar 

  12. Lesokhin, A.M., Callahan, M.K., Postow, M.A. & Wolchok, J.D. Sci. Transl. Med. 7, 280sr281 (2015).

    Article  Google Scholar 

Download references

Acknowledgements

This work was supported by US National Institutes of Health grant R01 CA169123.

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  1. Robert H. Vonderheide is at the Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.,

    Robert H Vonderheide

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  1. Robert H Vonderheide
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Correspondence to Robert H Vonderheide.

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Vonderheide, R. CD47 blockade as another immune checkpoint therapy for cancer. Nat Med 21, 1122–1123 (2015). https://doi.org/10.1038/nm.3965

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