A mouse model with combined renal epithelium-specific deletion of Vhl, Trp53 and Rb1 that develops clear-cell renal cell carcinoma provides a research tool for investigating the mechanisms that drive this cancer, and for evaluating the efficacy of novel therapeutic agents.
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Acknowledgements
This work was supported by the Intramural Research Program of the US National Institutes of Health (NIH), National Cancer Institute (NCI), Center for Cancer Research. This work has been funded in part with Federal funds from the Frederick National Laboratory for Cancer Research, NIH, under contract HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products or organizations imply endorsements by the US Government.
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Schmidt, L., Linehan, W. A mouse model of renal cell carcinoma. Nat Med 23, 802–803 (2017). https://doi.org/10.1038/nm.4366
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DOI: https://doi.org/10.1038/nm.4366
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