Sirt1, an enzyme that removes acetyl groups from specific nuclear proteins, has been linked to the regulation of aging. It is now clear that Sirt1 also controls hepatic glucose metabolism by serving as a sensor of the metabolic status in hepatocytes.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Astragalus polysaccharides attenuate rat aortic endothelial senescence via regulation of the SIRT-1/p53 signaling pathway
BMC Complementary Medicine and Therapies Open Access 08 February 2024
-
Epigenetic regulation of caloric restriction in aging
BMC Medicine Open Access 25 August 2011
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Bordone, L. & Guarente, L. Nat. Rev. Mol. Cell Biol. 6, 298–305 (2005).
Rodgers, J.T. et al. Nature 434, 113–118 (2005).
Lin, J. et al. Cell Metab. 1, 361–370 (2005).
Blander, G. & Guarente, L. Annu. Rev. Biochem. 73, 417–435 (2004).
McBurney, M.W. et al. Mol. Cell Biol. 23, 38–54 (2003).
Cheng, H.L. et al. Proc. Natl. Acad. Sci. USA 100, 10794–10799 (2003).
Picard, F. et al. Nature 429, 771–776 (2004).
Moynihan, K.A. et al. Cell Metab. 2, 105–117 (2005).
Nemoto, S. et al. J. Biol. Chem. 280, 16456–16460 (2005).
Imai, S. et al., Nature 403, 795–800 (2000).
Leibiger, I.B. & Berggren, P.O. Cell Metab. 2, 80–82 (2005).
Yoon, J.C. et al. Dev. Cell 5, 73–83 (2003).
Lin, J. et al. Cell 120, 261–273 (2005).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Leibiger, I., Berggren, PO. Sirt1: a metabolic master switch that modulates lifespan. Nat Med 12, 34–36 (2006). https://doi.org/10.1038/nm0106-34
Issue Date:
DOI: https://doi.org/10.1038/nm0106-34
This article is cited by
-
Astragalus polysaccharides attenuate rat aortic endothelial senescence via regulation of the SIRT-1/p53 signaling pathway
BMC Complementary Medicine and Therapies (2024)
-
The effects of metformin monotherapy and combination of metformin and glibenclamide therapy on the expression of RAGE, Sirt1, and Nrf2 genes in peripheral blood mononuclear cells of type 2 diabetic patients
Journal of Diabetes & Metabolic Disorders (2022)
-
The effects of olive leaf extract from a Sicilian cultivar in an experimental model of hepatic steatosis
Rendiconti Lincei (2017)
-
Caloric restriction: beneficial effects on brain aging and Alzheimer’s disease
Mammalian Genome (2016)
-
SIRT1 Activation Ameliorates Aldara-Induced Psoriasiform Phenotype and Histology in Mice
Journal of Investigative Dermatology (2015)