γ-secretase inhibitors inhibit Notch, a transmembrane receptor that drives many cases of T cell acute lymphoblastic leukemia—but there are safety concerns with such drugs. Combining these inhibitors with glucocorticoids could provide a more effective and safer approach (pages 50–58).
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Grosveld, G. γ-secretase inhibitors: Notch so bad. Nat Med 15, 20–21 (2009). https://doi.org/10.1038/nm0109-20
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DOI: https://doi.org/10.1038/nm0109-20
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