Adenosine therapy for sickle cell disease has been proposed to improve blood flow, mediate cytoprotection and inhibit natural killer cell activity. Complicating this approach, adenosine signaling also induces hemoglobin S polymerization, promoting 'sickling', vasoocclusion, hemolysis and organ damage (pages 79–86).
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Acknowledgements
I thank S. Tofovic and E. Jackson, University of Pittsburgh, for helpful comments and insights on adenosine biology.
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Gladwin, M. Adenosine receptor crossroads in sickle cell disease. Nat Med 17, 38–40 (2011). https://doi.org/10.1038/nm0111-38
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DOI: https://doi.org/10.1038/nm0111-38
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