Neuroblastoma is a fatal childhood cancer, but lack of knowledge about the underlying causative genes has hampered the development of effective therapies. The identification of anaplastic lymphoma kinase (ALK) mutations as drivers of neuroblastoma has indicated that targeted therapy with ALK inhibitors might be a valuable strategy in the fight against this lethal cancer.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Neuroblastoma treatment in the post-genomic era
Journal of Biomedical Science Open Access 08 February 2017
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Brodeur, G.M., Seeger, R.C., Schwab, M., Varmus, H.E. & Bishop, J.M. Science 224, 1121–1124 (1984).
Look, A.T. et al. J. Clin. Oncol. 9, 581–591 (1991).
Maris, J.M. N. Engl. J. Med. 362, 2202–2211 (2010).
Mossé, Y.P. et al. Nature 455, 930–935 (2008).
Janoueix-Lerosey, I. et al. Nature 455, 967–970 (2008).
Chen, Y. et al. Nature 455, 971–974 (2008).
George, R.E. et al. Nature 455, 975–978 (2008).
De Brouwer, S. et al. Clin. Cancer Res. 16, 4353–4362 (2010).
Sasaki, T. et al. Cancer Res. 70, 10038–10043 (2010).
McDermott, U. et al. Cancer Res. 68, 3389–3395 (2008).
Soda, M. et al. Nature 448, 561–566 (2007).
Kwak, E.L. et al. N. Engl. J. Med. 363, 1693–1703 (2010).
Lee, C.C. et al. Biochem. J. 430, 425–437 (2010).
Stoica, G.E. et al. J. Biol. Chem. 276, 16772–16779 (2001).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
A.W. is named as an inventor on Georgetown University patents that are related to the ALK receptor.
Rights and permissions
About this article
Cite this article
Wellstein, A., Toretsky, J. Hunting ALK to feed targeted cancer therapy. Nat Med 17, 290–291 (2011). https://doi.org/10.1038/nm0311-290
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm0311-290
This article is cited by
-
Neuroblastoma treatment in the post-genomic era
Journal of Biomedical Science (2017)
-
ALK-Mutated Non-Small-Cell Lung Cancer: A New Strategy for Cancer Treatment
Lung (2012)