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Reply to "Tissue plasminogen activator and NMDA receptor cleavage"

Nature Medicine volume 9, pages 372–373 (2003)Cite this article

A Corrigendum to this article was published on 01 July 2003

Nicole et al. reply

We showed that TPA, a serine protease known for its fibrinolytic activity, enhances NMDA-mediated calcium signaling and subsequent excitotoxic neuronal injury. This potentiation of excitotoxicity is concomitant with the cleavage of the NR1 subunit of NMDA receptor by TPA5.

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References

  1. Gingrich, M.B. & Traynelis, S.F. Serine proteases and brain damage - is there a link? Trends. Neurosci. 23, 399–407 (2000).

    Article  CAS  Google Scholar 

  2. Chen, Z.L. et al. Neuronal death and blood-brain barrier breakdown after excitotoxic injury are independent processes. J. Neurosci. 19, 9813–9820 (1999).

    Article  CAS  Google Scholar 

  3. Pawlak, R. & Strickland, S. Tissue plasminogen activator and seizures: a clot-buster's secret life. J. Clin. Invest. 109, 1529–1531 (2002).

    Article  CAS  Google Scholar 

  4. Centonze, D. et al. Tissue plasminogen activator is required for corticostriatal long-term potentiation. Eur. J. Neurosci. 16, 713–721 (2002).

    Article  Google Scholar 

  5. Nicole, O. et al. The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling. Nat. Med. 7, 59–64 (2001).

    Article  CAS  Google Scholar 

  6. Ponting, C.P., Marshall, J.M. & Cederholm-Williams, S.A. Plasminogen: a structural review. Blood. Coagul. Fibrinolysis 3, 605–614 (1992).

    Article  CAS  Google Scholar 

  7. Traynelis, S.F. & Lipton, S.A. Is tissue plasminogen activator a threat to neurons? Nat. Med. 7, 17–18 (2001).

    Article  CAS  Google Scholar 

  8. Gingrich, M.B., Junge, C.E., Lyuboslavsky, P. & Traynelis, S.F. Potentiation of NMDA receptor function by the serine protease thrombin. J. Neurosci. 20, 4582–4595 (2000).

    Article  CAS  Google Scholar 

  9. Inoue, K., Koizumi, S., Nakajima, K., Hamanoue, M. & Kohsaka, S. Modulatory effect of plasminogen on NMDA-induced increase in intracellular free calcium concentration in rat cultured hippocampal neurons. Neurosci. Lett. 179, 87–90 (1994).

    Article  CAS  Google Scholar 

  10. Mizutani, A., Tanaka, T., Saito, H. & Matsuki, N. Postsynaptic blockade of inhibitory postsynaptic currents by plasmin in CA1 pyramidal cells of rat hippocampus. Brain. Res. 761, 93–96 (1997).

    Article  CAS  Google Scholar 

  11. Fernandez-Monreal, M. et al. Modulation of the NMDA receptor function by tissue-type plasminogen activator. Soc. Neurosci. Abstr. 747, 11 (2002).

    Google Scholar 

  12. Nagai, N., De Mol, M., Lijnen, H.R., Carmeliet, P. & Collen, D. Role of plasminogen system components in focal cerebral ischemic infarction: a gene targeting and gene transfer study in mice. Circulation 99, 2440–2444 (1999).

    Article  CAS  Google Scholar 

  13. Rogove, A.D., Siao, C., Keyt, B., Strickland, S. & Tsirka, S.E. Activation of microglia reveals a non-proteolytic cytokine function for tissue plasminogen activator in the central nervous system. J. Cell. Sci. 112, 4007–4016 (1999).

    CAS  PubMed  Google Scholar 

  14. Tsirka, S.E., Rogove, A.D., Bugge, T.H., Degen, J.L. & Strickland, S. An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus. J. Neurosci. 17, 543–552 (1997).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Université de Caen, Cyceron, UMR 6551, France

    Denis Vivien, Monica Fernandez Monréal, Olivier Nicole & Alain Buisson

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  1. Denis Vivien
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  2. Monica Fernandez Monréal
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  3. Olivier Nicole
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  4. Alain Buisson
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Correspondence to Alain Buisson.

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Vivien, D., Monréal, M., Nicole, O. et al. Reply to "Tissue plasminogen activator and NMDA receptor cleavage". Nat Med 9, 372–373 (2003). https://doi.org/10.1038/nm0403-372

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