Axonal damage causes neurological defects in multiple sclerosis. In vivo imaging in mouse models of multiple sclerosis now shows a reversible and sequential process of focal axonal degeneration (FAD) (pages 495–499), suggesting the use of neuroregenerative as well as neuroprotective drugs as potential therapies for multiple sclerosis.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Bjartmar, C., Kidd, G., Mork, S., Rudick, R. & Trapp, B.D. Ann. Neurol. 48, 893–901 (2000).
Hemmer, B. & Hartung, H.P. Ann. Neurol. 62, 314–326 (2007).
Nikic´, I. et al. Nat. Med. 17, 495–499 (2011).
Frischer, J.M. et al. Brain 132, 1175–1189 (2009).
Trapp, B.D. & Nave, K.A. Annu. Rev. Neurosci. 31, 247–269 (2008).
Scalfari, A. et al. Brain 133, 1914–1929 (2010).
Leray, E. et al. Brain 133, 1900–1913 (2010).
Edan, G. & Leray, E. J. Neurol. Sci. published online, 10.1016/j.jns.2010.09.018 (16 October 2010).
DeLuca, G.C., Ebers, G.C. & Esiri, M.M. Brain 127, 1009–1018 (2004).
Vergo, S., et al. Brain 134, 571–584 (2011).
Dutta, R. et al. Ann. Neurol. 59, 478–489 (2006).
Satoh, T. & Lipton, S.A. Trends Neurosci. 30, 37–45 (2007).
Stirling, D.P. & Stys, P.K. Trends Mol. Med. 16, 160–170 (2010).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Craner, M., Fugger, L. Axonal injury in reverse. Nat Med 17, 423–425 (2011). https://doi.org/10.1038/nm0411-423
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm0411-423