Humans with a missense mutation in LRP5 (encoding lipoprotein receptor-related protein 5) have a high bone mass phenotype, which has now been recapitulated in mice conditionally expressing this Lrp5 variant in terminally differentiated bone osteocytes (pages 684–691). These results suggest that LRP5 acts locally to increase bone mass, thereby opening avenues for new therapeutics for osteoporosis and bone injury by manipulating LRP5 signaling.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Johnson, M.L. et al. Am. J. Hum. Genet. 60, 1326–1332 (1997).
Gong, Y. et al. Cell 107, 513–523 (2001).
Little, R.D. et al. Am. J. Hum. Genet. 70, 11–19 (2002).
Kato, M. et al. J. Cell Biol. 157, 303–314 (2002).
Babij, P. et al. J. Bone Miner. Res. 18, 960–974 (2003).
Baron, R. & Rawadi, G. Curr. Osteoporos. Rep. 5, 73–80 (2007).
Cui, Y. et al. Nat. Med. 17, 684–691 (2011).
Lu, Y. et al. J. Dent. Res. 86, 320–325 (2007).
Bonewald, L.F. J. Bone Miner. Res. 26, 229–238 (2011).
Yadav, V.K. et al. Cell 135, 825–837 (2008).
Sawakami, K. et al. J. Biol. Chem. 281, 23698–23711 (2006).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Bonewald, L. The holy grail of high bone mass. Nat Med 17, 657–658 (2011). https://doi.org/10.1038/nm0611-657
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm0611-657
This article is cited by
-
LRP5 and bone mass regulation: Where are we now?
BoneKEy Reports (2012)