Genome instability and DNA repair defects have been discovered in the premature aging disease Hutchinson-Gilford progeria syndrome. These findings provide the first hint of a molecular mechanism for a group of human conditions caused by defects in the nuclear structural protein lamin A (pages 780–785).
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Misteli, T., Scaffidi, P. Genome instability in progeria: when repair gets old. Nat Med 11, 718–719 (2005). https://doi.org/10.1038/nm0705-718
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DOI: https://doi.org/10.1038/nm0705-718
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