One of the body's key defenders against infection—the activated macrophage—engulfs bacteria and destroys them with an acid cocktail inside lysosomes. Mycobacterium tuberculosis seems to have evolved a strategy to cope with this threat (pages 849–854).
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Katie Ris-Vicari
References
Russell, D.G. Nat. Rev. Mol. Cell Biol. 2, 569–577 (2001).
Armstrong, J.A. & Hart, P.D. J. Exp. Med. 134, 713–740 (1971).
Chapman, J.S. & Bernard, J.S. Am. Rev. Respir. Dis. 86, 582–583 (1962).
Vandal, O.H., Pierini, L.M., Schnappinger, D., Nathan, C. & Ehrt, S. Nat. Med. 14, 849–854 (2008).
MacMicking, J.D., Taylor, G.S. & McKinney, J.D. Science 302, 654–659 (2003).
Lillebaek, T. et al. J. Infect. Dis. 185, 401–404 (2002).
Munoz-Elias, E.J. & McKinney, J.D. Nat. Med. 11, 638–644 (2005).
Fisher, M.A., Plikaytis, B.B. & Shinnick, T.M. J. Bacteriol. 184, 4025–4032 (2002).
Rohde, K.H., Abramovitch, R.B. & Russell, D.G. Cell Host Microbe 2, 352–364 (2007).
Gandotra, S., Schnappinger, D., Monteleone, M., Hillen, W. & Ehrt, S. Nat. Med. 13, 1515–1520 (2007).
Ng, V.H., Cox, J.S., Sousa, A.O., MacMicking, J.D. & McKinney, J.D. Mol. Microbiol. 52, 1291–1302 (2004).
Darwin, K.H., Ehrt, S., Gutierrez-Ramos, J.C., Weich, N. & Nathan, C.F. Science 302, 1963–1966 (2003).
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MacMicking, J. M. tuberculosis passes the litmus test. Nat Med 14, 809–810 (2008). https://doi.org/10.1038/nm0808-809
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DOI: https://doi.org/10.1038/nm0808-809
