Abstract
The similarities and differences between normal tissue stem cells and cancer stem cells (CSCs) have been the source of much contention, with some recent studies calling into question the very existence of CSCs. An examination of the literature indicates, however, that the CSC model rests on firm experimental foundations and that differences in the observed frequencies of CSCs within tumors reflect the various cancer types and hosts used to assay these cells. Studies of stem cells and the differentiation program termed the epithelial-mesenchymal transition (EMT) point to the possible existence of plasticity between stem cells and their more differentiated derivatives. If present, such plasticity would have major implications for the CSC model and for future therapeutic approaches.
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References
Kelly, P.N., Dakic, A., Adams, J.M., Nutt, S.L. & Strasser, A. Science 317, 337 (2007).
Quintana, E. et al. Nature 456, 593–598 (2008).
Clarke, M.F. et al. Cancer Res. 66, 9339–9344 (2006).
Lapidot, T. et al. Nature 367, 645–648 (1994).
Al-Hajj, M., Wicha, M.S., Benito-Hernandez, A., Morrison, S.J. & Clarke, M.F. Proc. Natl. Acad. Sci. USA 100, 3983–3988 (2003).
Singh, S.K. et al. Cancer Res. 63, 5821–5828 (2003).
Bonnet, D. & Dick, J.E. Nat. Med. 3, 730–737 (1997).
Harris, M.A. et al. Cancer Res. 68, 10051–10059 (2008).
Thon, N. et al. Mol. Cell Neurosci. published online, doi: 10.1016/j.mcn.2008.07.022 (7 August 2008).
Chiou, S.H. et al. Clin. Cancer Res. 14, 4085–4095 (2008).
Honeth, G. et al. Breast Cancer Res. 10, R53 (2008).
Kennedy, J.A., Barabe, F., Poeppl, A.G., Wang, J.C. & Dick, J.E. Science 318, 1722 (2007).
Zhang, M. et al. Cancer Res. 68, 4674–4682 (2008).
Cho, R.W. et al. Stem Cells 26, 364–371 (2008).
Deshpande, A.J. et al. Cancer Cell 10, 363–374 (2006).
Wu, A. et al. Stem Cells Dev. 17, 173–184 (2008).
Mani, S.A. et al. Cell 133, 704–715 (2008).
Morel, A.P. et al. PLoS One 3, e2888 (2008).
Thiery, J.P. Curr. Opin. Cell Biol. 15, 740–746 (2003).
Hugo, H. et al. J. Cell. Physiol. 213, 374–383 (2007).
Brabletz, T. et al. Proc. Natl. Acad. Sci. USA 98, 10356–10361 (2001).
Yook, J.I. et al. Nat. Cell Biol. 8, 1398–1406 (2006).
Till, J.E., McCulloch, E.A. & Siminovitch, L. Proc. Natl. Acad. Sci. USA 51, 29–36 (1964).
Santisteban, M. et al. Cancer Res. 69, 2887–2895 (2009).
Clarkson, B. & Strife, A. Leuk. Lymphoma 11, 101–107 (1993).
Barr, S. et al. Clin. Exp. Metastasis 25, 685–693 (2008).
Buck, E. et al. Cancer Res. 68, 8322–8332 (2008).
Li, X. et al. J. Natl. Cancer Inst. 100, 672–679 (2008).
Thomson, S. et al. Cancer Res. 65, 9455–9462 (2005).
Woodward, W.A. et al. Proc. Natl. Acad. Sci. USA 104, 618–623 (2007).
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Gupta, P., Chaffer, C. & Weinberg, R. Cancer stem cells: mirage or reality?. Nat Med 15, 1010–1012 (2009). https://doi.org/10.1038/nm0909-1010
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DOI: https://doi.org/10.1038/nm0909-1010
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