Mouse experiments show how mutation of a gene involved in human epilepsy causes hyperexcitability of the neuronal network (pages 1208–1214). The mutations interfere with the maturation of excitatory synapses during postnatal development.
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Caleo, M. Epilepsy: synapses stuck in childhood. Nat Med 15, 1126–1127 (2009). https://doi.org/10.1038/nm1009-1126
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DOI: https://doi.org/10.1038/nm1009-1126
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Postsynaptic movement disorders: clinical phenotypes, genotypes, and disease mechanisms
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