Amantadine, a proton-channel blocker used to treat influenza, also inhibits growth of the malaria parasite Plasmodium falciparum. The drug is most active against parasite strains resistant to the increasingly ineffective drug chloroquine. The molecular basis of this enhanced activity is now examined, opening the door to new ways to attack chloroquine resistance.
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Wellems, T. Transporter of a malaria catastrophe. Nat Med 10, 1169–1171 (2004). https://doi.org/10.1038/nm1104-1169
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DOI: https://doi.org/10.1038/nm1104-1169
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