Abstract
New findings suggest that B cells are not as important for prion replication in peripheral tissues and for prion transport to the central nervous system as previously thought (pages 1429–1433)
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Prion disease: experimental models and reality
Acta Neuropathologica Open Access 13 January 2017
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Klein, M.A. et al. PrP expression in B lymphocytes is not required for prion neuroinvasion. Nature Med. 4, 1429– 1433 (1998).
Collinge, J., Sidle, K.C.L., Meads, J., Ironside, J. & Hill, A.F. Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD. Nature 383, 685–690 (1996).
Hill, A.F. et al. The same prion strain causes vCJD and BSE. Nature 389, 448–450 (1997).
Bruce, M.E. et al. Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent. Nature 389, 498–501 (1997).
Hill, A.F., Zeidler, M., Ironside, J. & Collinge, J. Diagnosis of new variant Creutzfeldt-Jakob disease by tonsil biopsy. Lancet 349, 99–100 (1997).
Hilton, D.A., Fathers, E., Edwards, P., Ironside, J.W. & Zajicek, J. Prion immunoreactivity in appendix before clinical onset of variant Creutzfeldt-Jakob disease. Lancet 352, 703–704 (1998).
Fraser, H. & Farquhar, C.F. Ionising radiation has no influence on scrapie incubation period in mice. Vet.Microbiol. 13, 211–223 (1987).
Clarke, M. C. & Kimberlin, R. H. Multiplication of scrapie agent in mouse spleen. Res Vet Sci. 9, 215– 225 (1984).
Klein, M.A. et al. A crucial role for B cells in neuroinvasive scrapie. Nature 390, 687–690 (1997).
Bueler, H. et al. Mice devoid of PrP are resistant to scrapie. Cell 73, 1339–1347 (1993).
Blattler, T. et al. PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain. Nature 389, 69– 73 (1997).
Kimberlin, R.H. & Walker, C.A. Pathogenesis of mouse scrapie: Evidence for neural spread of infection to the CNS. J. Gen. Virol. 51, 183–187 (1980).
Lasmezas, C.I. et al. Immune system-dependent and -independent replication of the scrapie agent. J.Virol. 70, 1292– 1295 (1996).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Collinge, J., Hawke, S. B lymphocytes in prion neuroinvasion: Central or peripheral players? . Nat Med 4, 1369–1370 (1998). https://doi.org/10.1038/3955
Issue Date:
DOI: https://doi.org/10.1038/3955
This article is cited by
-
Prion disease: experimental models and reality
Acta Neuropathologica (2017)
-
Creutzfeldt-Jakob disease and the eye. I. Background and patient management
Eye (2000)