Cysts were generated from organoids in vitro and the removal of adherent cues was shown to play a key role in polycystic kidney disease progression. These cysts resembled those of diseased tissue phenotypically and were capable of remodelling their microenvironment.
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References
Cruz, N. M. et al. Nat. Mater. 16, 1112–1119 (2017).
Ong, A. C., Devuyst, O., Knebelmann, B. & Walz, G. Lancet 385, 1993–2002 (2015).
Rossetti, S. & Harris, P. C. J. Am. Soc. Nephrol. 18, 1374–1380 (2007).
Happé, H. & Peters, D. J. Nat. Rev. Nephrol. 10, 587–601 (2014).
Carone, F. A. et al. Kidney Int. 47, 861–868 (1995).
O'Brien, L. E. et al. Nat. Cell Biol. 3, 831–838 (2001).
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Romagnani, P. Modelling polycystic kidney disease. Nature Mater 16, 1058–1059 (2017). https://doi.org/10.1038/nmat5013
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DOI: https://doi.org/10.1038/nmat5013