Reagents that recognize specific chemical modifications while ignoring the surrounding protein offer valuable proteomic insights.
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References
Kee, J.-M. et al. A pan-specific antibody for direct detection of protein histidine phosphorylation. Nat. Chem. Biol. doi:10.1038/nchembio.1259 (26 May 2013).
Moore, K.E. et al. A general molecular affinity strategy for global detection and proteomic analysis of lysine methylation. Mol. Cell 50, 444–456 (2013).
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Eisenstein, M. Matching marks with mechanisms. Nat Methods 10, 604–605 (2013). https://doi.org/10.1038/nmeth.2546
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DOI: https://doi.org/10.1038/nmeth.2546