Single-cell 5hmC sequencing uncovers cell-to-cell differences in the two DNA strands of a given chromosome.
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References
Mooijman, D. et al. Single-cell 5hmC sequencing reveals chromosome-wide cell-to-cell variability and enables lineage reconstruction. Nat. Biotechnol. 34, 852–856 (2016).
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Jarchum, I. Tracing cell lineage with 5hmC. Nat Methods 13, 710–711 (2016). https://doi.org/10.1038/nmeth.3986
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DOI: https://doi.org/10.1038/nmeth.3986