Abstract
Temporal and quantitative relations between excitatory and inhibitory inputs in the cortex are central to its activity, yet they remain poorly understood. In particular, a controversy exists regarding the extent of correlation between cortical excitation and inhibition. Using simultaneous intracellular recordings in pairs of nearby neurons in vivo, we found that excitatory and inhibitory inputs are continuously synchronized and correlated in strength during spontaneous and sensory-evoked activities in the rat somatosensory cortex.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Chance, F.S., Abbott, L.F. & Reyes, A.D. Neuron 35, 773–782 (2002).
Shadlen, M.N. & Newsome, W.T. J. Neurosci. 18, 3870–3896 (1998).
Rudolph, M., Pospischil, M., Timofeev, I. & Destexhe, A. J. Neurosci. 27, 5280–5290 (2007).
Las, L., Stern, E.A. & Nelken, I. J. Neurosci. 25, 1503–1513 (2005).
DeWeese, M.R. & Zador, A.M. J. Neurosci. 26, 12206–12218 (2006).
Crochet, S. & Petersen, C.C. Nat. Neurosci. 9, 608–610 (2006).
Wehr, M. & Zador, A.M. Nature 426, 442–446 (2003).
Gabernet, L., Jadhav, S.P., Feldman, D.E., Carandini, M. & Scanziani, M. Neuron 48, 315–327 (2005).
Haider, B., Duque, A., Hasenstaub, A.R. & McCormick, D.A. J. Neurosci. 26, 4535–4545 (2006).
Lampl, I., Reichova, I. & Ferster, D. Neuron 22, 361–374 (1999).
Petersen, C.C., Hahn, T.T., Mehta, M., Grinvald, A. & Sakmann, B. Proc. Natl. Acad. Sci. USA 100, 13638–13643 (2003).
Hasenstaub, A. et al. Neuron 47, 423–435 (2005).
Lestienne, R. Prog. Neurobiol. 65, 545–591 (2001).
Deweese, M.R. & Zador, A.M. J. Neurophysiol. 92, 1840–1855 (2004).
Pinto, D.J., Hartings, J.A., Brumberg, J.C. & Simons, D.J. Cereb. Cortex 13, 33–44 (2003).
Acknowledgements
We would like to thank E. Ahissar, I. Nelken, E. Schneidman and O. Barak for their comments on the manuscript, and all the members of the Lampl lab for their helpful contribution to this work. This work was supported by grants from the Israel Science Foundation (1037/03, 326/07), the National Institute for Psychobiology in Israel, the Henry S. and Anne Reich Research Fund for Mental Health, the Asher and Jeanette Alhadeff Research Award and the Sir Charles Clore fellowship.
Author information
Authors and Affiliations
Corresponding author
Supplementary information
Supplementary Text and Figures
Supplementary Figures 1–8, Methods and Results (PDF 1720 kb)
Rights and permissions
About this article
Cite this article
Okun, M., Lampl, I. Instantaneous correlation of excitation and inhibition during ongoing and sensory-evoked activities. Nat Neurosci 11, 535–537 (2008). https://doi.org/10.1038/nn.2105
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/nn.2105
This article is cited by
-
Control of neuronal excitation–inhibition balance by BMP–SMAD1 signalling
Nature (2024)
-
On the physiological and structural contributors to the overall balance of excitation and inhibition in local cortical networks
Journal of Computational Neuroscience (2024)
-
Graph theoretical brain connectivity measures to investigate neural correlates of music rhythms associated with fear and anger
Cognitive Neurodynamics (2024)
-
Uncovering hidden network architecture from spiking activities using an exact statistical input-output relation of neurons
Communications Biology (2023)
-
Learning how network structure shapes decision-making for bio-inspired computing
Nature Communications (2023)